Carisoprodol (trade names embrace Soma, Somadril, Carisoma, Carisoprodol Watson, Listaflex, Somacid, Vanadom) is a muscle relaxant from carbamic acid esters pharmacological group. This medication is indicated together with relaxation and physical therapy to alleviate musculoskeletal ache, skeletal muscle spasms, stiffness, muscle injuries, strain, sprain, acute again ache, discomfort related to short-term, painful musculoskeletal situations, and for other medical purposes. It can be widely off-label used as recreational drug. Carisoprodol may be prescribed alone for monotherapy or in combinations with different medication, such as psycholeptics.
Clinical presentation </h2
Overdosage of Carisoprodol (Soma) tablets commonly produces CNS depression. Death, coma, respiratory depression, hypotension, seizures, delirium, hallucinations, dystonic reactions, nystagmus, blurred imaginative and prescient, mydriasis, euphoria, muscular incoordination, rigidity, and/or headache have been reported with Soma overdosage. Serotonin syndrome has been reported with carisoprodol intoxication. Many of the carisoprodol overdoses have occurred within the setting of a number of drug overdoses (including drugs of abuse, unlawful drugs, and alcohol). The effects of an overdose of this treatment and different CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants) may be additive even when one of many medicine has been taken within the recommended dosage. Fatal unintended and non-accidental overdoses of SOMA have been reported alone or in combination with CNS depressants.
Treatment of overdosage
Basic life assist measures must be instituted as dictated by the clinical presentation of the Soma overdose. Vomiting shouldn’t be induced because of the risk of CNS and respiratory melancholy, and subsequent aspiration. Circulatory support must be administered with volume infusion and vasopressor agents if wanted. Seizures ought to be treated with intravenous benzodiazepines and the reoccurrence of seizures could also be handled with phenobarbital. In circumstances of severe CNS despair, airway protecting reflexes could also be compromised and tracheal intubation should be considered for airway safety and respiratory help.
For decontamination in circumstances of severe toxicity, activated charcoal ought to be thought-about in a hospital setting in sufferers with giant overdoses who present early and are not demonstrating CNS melancholy and can protect their airway.